Geopolitics, often overlooked in the realm of global health, holds significant influence over our understanding, addressing, and overcoming health challenges. By shifting our focus towards geopolitics, we can gain a better comprehension of the forces that shape the economic, social, and physical landscapes affecting the health of individuals. This includes a critical examination of international, regional and national governance mechanisms including the United Nations and Bretton Woods institutions. Recent years, there has been a renewed focus on addressing persistent inequalities in influence, resources, and health, shedding light on historical injustices such as colonialism and imperialism contributing to health inequities and impacting progress on the Sustainable Development Goals (SDGs) and the pledge to leave no one behind.